Matthew Rouhier joined the faculty at Kenyon College in the fall of 2013 following two postdoctoral appointments. His first appointment was at the Center for Childhood Cancer at Nationwide Children’s Hospital where he studied the relationship between RNA splicing and pediatric disease. His second appointment was at Ohio State University’s – Ohio Agricultural Research and Development Center in Wooster, Ohio where he investigated small molecule blockers of potassium transporters as possible mosquitocides.
His current research is exploring mosquito-borne diseases and the mechanisms of xenobiotic transport in the yellow fever mosquito, Aedes aegypti and the Asian tiger mosquito, Aedes albopictus.
Areas of Expertise
Biochemistry, RNA splicing, ion channels.
Courses Recently Taught
BIOL 267
Experimental Cell Biology
BIOL 267
This laboratory course is designed to complement BIOL 266. The topics covered in the laboratory will expose the student to some of the standard techniques used in modern cell biology. The laboratories also will illustrate some of the fundamental ideas of the field. Instead of covering a wide variety of techniques and preparations superficially, we will concentrate on a select few, covering them in greater depth. Some topics that will be covered are protein separation, cell permeability and cell motility. Prerequisite: BIOL 109Y-110Y. Prerequisite or corequisite: BIOL 266. Generally offered every other year. This counts toward the upper-level laboratory requirement.
CHEM 121
Introductory Chemistry
CHEM 121
This course provides a thorough introduction to the fundamental concepts, theories, and methodologies of chemistry. Topics may include stoichiometry, theories of molecular structure and bonding, the periodic table, acid-base chemistry, chemical equilibria and thermodynamics. This course provides a basis for the further study of chemistry. No prerequiste. Offered every fall semester.
CHEM 123
Introductory Chemistry Lab I
CHEM 123
This laboratory course accompanies CHEM 121 and 122 with an introduction to modern experimental chemistry. Laboratory experiments explore inorganic synthesis, molecular structure and properties, and spectroscopy, with an emphasis on laboratory safety, computerized data acquisition and analysis, and the theory of analytical instrumentation. The laboratory work is organized around individual and team projects. Communication skills are developed through proper use of a laboratory notebook. One three-hour laboratory is held per week. Corequisite: CHEM 121 or 122. Offered every fall semester.
CHEM 126
Introductory Chemistry Lab II
CHEM 126
This lab is an experimental course to accompany CHEM 124 or 243. One three-hour laboratory session will be held per week. Juniors and seniors may enroll with permission of department chair. Prerequisite: CHEM 123. Offered every spring semester.\n\nBiophysical and Medicinal Chemistry Lab sections\nLaboratory experiments involve the application of chemical principles and techniques to systems of biological and medicinal importance. Possible experiments include synthesis of aspirin, enzyme kinetics and chromatographic analysis.\n\nNanoscience Lab section\nLaboratory experiments involve the synthesis of functional materials, the analysis of their properties and the assembly of materials into working devices. Possible experiments include making solar cells, synthesis of nanocrystalline materials, quantum dots and an independent project.\n\nSpectroscopic Analysis sections\nLaboratory experiments involve quantitative analysis of materials using molecular spectroscopy, such as NMR, IR and UV/Vis spectroscopy. Possible experiments include identification of pharmaceutical or fragrance mixtures, polymer characterization, determination of equilibrium constants, and testing of food or drug products.
CHEM 191
ST: Chemistry in Context
CHEM 191
CHEM 371
Advanced Lab: Biochemistry
CHEM 371
This course is an introduction to fundamental laboratory techniques in biochemistry. The focus of the course is the isolation, purification, characterization and detailed kinetic analysis of alkaline of an enzyme of interest. This course meets for one three-hour laboratory period per week. Prerequisite or corequisite: CHEM 256. Offered every spring semester.
CHEM 401
Chemistry and Biochemistry Seminar
CHEM 401
Selected topics in advanced chemistry and biochemistry are explored with an emphasis on reading and discussing current scientific research and literature. Sections will include the following: Biophysical Chemistry, Advanced Organic Chemistry, Art and Chemistry, Chemical Biology, Hydrogen Energy Systems, Enzyme Mechanism, Emerging Techniques in Biological Chemistry and Advanced Biochemistry. Offered every semester, sections will change. Please see the schedule of courses each semester for the section being taught.
INDS 101
Intro to Research Meth in STEM
INDS 101
INDS 120
Methods for Promoting Science Understanding
INDS 120
This course is a community engaged course where students will learn how to promote the understanding of STEM sciences to the general public of Knox County. The objectives of this course revolve around a service learning project with our community partner, SPI (where Science and Play Intersect!) of Mt. Vernon. The course participants will read primary literature about science learning, generate new scientific communications, work as teams to produce science installations and will further their own understanding of the principles of STEM. This course involves several trips to SPI, the main floor of the Wright Center in Mt. Vernon, so students will need to arrange their own transportation or ride the Knox Area Transit’s Purple Shuttle to attend some classes. No prerequisite.
INDS 191
ST:Methods Promoting Science
INDS 191
INDS 191
ST: Methods Promoting Science
INDS 191
Academic & Scholarly Achievements
2014
Stress-Induced Alternative Splice Forms of MDM2 and MDMX Modulate the
p53-Pathway in Distinct Ways.
Jacob AG, Singh RK, Comiskey DF Jr, Rouhier MF, Mohammad F, Bebee TW,
Chandler DS.
PLoS One. 2014 Aug 8;9(8):e104444. doi: 10.1371/journal.pone.0104444.
eCollection 2014.
PMID: 25105592
2014
Pharmacological validation of an inward-rectifier potassium (Kir)
channel as an insecticide target in the yellow fever mosquito Aedes
aegypti.
Rouhier MF, Raphemot R, Denton JS, Piermarini PM.
PLoS One. 2014 Jun 24;9(6):e100700. doi: 10.1371/journal.pone.0100700.
eCollection 2014.
PMID: 24959745
2014
Identification of life-stage and tissue-specific splice variants of an
inward rectifying potassium (Kir) channel in the yellow fever mosquito
Aedes aegypti.
Rouhier MF, Piermarini PM.
Insect Biochem Mol Biol. 2014 May;48:91-9. doi:
10.1016/j.ibmb.2014.03.003. Epub 2014 Mar 18.
PMID: 24657620
2013
Eliciting renal failure in mosquitoes with a small-molecule inhibitor
of inward-rectifying potassium channels.
Raphemot R, Rouhier MF, Hopkins CR, Gogliotti RD, Lovell KM, Hine RM,
Ghosalkar D, Longo A, Beyenbach KW, Denton JS, Piermarini PM.
PLoS One. 2013 May 29;8(5):e64905. doi: 10.1371/journal.pone.0064905.
Print 2013.
PMID: 23734226